Public Lab

C 3 ( Complement 3 level )

Rate: Rs. 950

Sample

This test is done on serum or plasma (EDTA) of patient.

Assay should be done immediatly or store sample at -70C.

Important Facts

1.Complement consists of group of 25 proteins given numerical names as C1 to C9 and subunits.

2.These are present in the serum and give nonspecific inflammatory response to various antigens.

3.Complement is part of immune system and particularly C3 is very significant to prevent infections.

Complement C3 is a blood test that measures the activity of a certain protein that is part of the complement system.

This occupy the position where Classical and alternative pathways join and from there common pathway or terminal pathway starts.

This test is performed for to find out the deficiency of Complement 3.

Purpose

A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement proteins C3 and C4.

In case of C3 deficiency there are more chances for repeated infections.

The normal range

Cord serum :65-111.8 mg/dl

Child 6 month: 86-135 mg/dl

Adult : 83—177 mg/dl

Decreased complement activity may be seen in:

1.Hereditary angioedema

2.Bacterial infections (especially Neisseria)

3.Cirrhosis

4.Glomerulonephritis

5.Hepatitis

6.Lupus nephritis

7.Malnutrition

8.Kidney transplant rejection

9.Systemic lupus erythematosus

10.Congenital:

1.C3 deficiency associated with recurrent pyogenic infection.

2.C3 may be decreased due to congenital deficiency of contron proteins, factor H,and I.

11.Acquired :

1.may be senn decreased in various types of infections and inflammatory conditions.

2.Primary cause is immune complex disease like SLE, Rheumatoid arthritis, Subacute bacterial endocarditis.

3.Viremia, paarasitemia, and bacterial sepsis.

4.In membranoglomerulitis.

Increased C3 may be seen in

1.Acute phase protien in Rheumatic fever,viral hepatitis,

mycardial infarction,cancers, diabetes, and pregnancy.

1.in Sarcoidosis and Amyloidosis.

2.Thyroiditis.

3.Inflammatory bowel disease.

4.Typhoid fever.

5.Pneumococcal pneumonia.